The wedding will be held in a northern area of San Diego, but most of the events including the after party will be in a more central part of San Diego. Aside from hotels listed below, Airbnb and VRBO have great options as well. Here's some guidance on areas to stay:
 

Beach areas

Pacific Beach

Ocean Beach

Bird Rock / La Jolla

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Vibey areas

Little Italy / Downtown

Hillcrest / Mission Hills

North Park

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Hotels Near the Venue

La Valencia
Grande Colonial
La Jolla Shores Hotel

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Hotels in Central San Diego

Pendry  -  trendy hotel in Downtown's Gaslamp District, close to the afterparty.
Lafayette  -  trendy hotel in Central San Diego, good pool scene.
Kimpton  -  downtown San Diego, overlooking the bay, and close to the after party.
Inn at the park  -  near beautiful Balboa Park (where Spencer and Jane got engaged!). A great

place for morning walks.

Hotel Del  -  famous San Diego hotel. A bit farther away from all the activity but very charming

and right on the beach!

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